The role of SR-BⅡ in the oxidized low density lipid induced foam cell formation promoted by porphyromonas gingivalis
10.3969/j.issn.1001-3733.2017.03.005
- VernacularTitle:B类Ⅱ型清道夫受体在牙龈卟啉单胞菌影响泡沫细胞形成中的作用
- Author:
Xiaoli HE
;
Dongyu LIANG
;
Feng LIU
;
Jianxia CHEN
;
Lijun LUO
- Keywords:
Porphyromonas gingivalis;
Scavenger receptor BⅡ(SR-BⅡ);
Foam cell;
Oxidized low density lipid(ox-LDL)
- From:
Journal of Practical Stomatology
2017;33(3):306-311
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of scavenger receptor BⅡ(SR-BⅡ) in the oxidized low density lipid(ox-LDL) induced foam cells formation promoted by porphyromonas gingivalis(P.g).Methods:Peritoneal macrophages were stimulated with P.g and ox-LDL,and then foam cells formation were checked.The expression of SR-BⅡ was detected by Western blot and real-time PCR.Next,siRNA targeting SR-BⅡ was used to detect the change of foam cells formation.Results:After being stimulated with P.g and ox-LDL,the foam cells formation was significantly increased.During the process of foam cells formation,P.g infection increased the expression of SR-BⅡ.And the knockdown of SR-BⅡ by siRNA significantly reduced the foam cells formation.Conclusion:P.g infection can increase the expression of SR-BⅡ and the regulation of SR-BⅡ expression can change the foam cells formation.
