Effect of drug therapy on the expression of serum adiponectin in patients with Graves disease hyperthyroidism
10.3969/j.issn.1673-4130.2017.10.022
- VernacularTitle:药物治疗对Graves病甲亢患者血清脂联素表达水平的影响
- Author:
Huilin PEI
- Keywords:
Graves disease;
hyperthyroidism;
serum;
adiponectin
- From:
International Journal of Laboratory Medicine
2017;38(10):1349-1351
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the hyperthyroidism patients with Graves disease before and after treatment serum adiponectin level changes.Methods 108 cases of hyperthyroidism patients with Graves disease as the research object,they are divided into GD1 and GD2 two subgroups,and the other in the same period to our line of health inspection in 50 cases of healthy controls,fully explore hyperthyroidism before and after treatment in patients with Graves disease changes of the serum adiponectin level.Results Compared with healthy controls,GD1 group of adiponectin level is higher,the GD2 group of the low level of adiponectin,compared with those of GD2 group had significantly higher GD1 group,P<0.05.Data statistical differences between groups,P<0.05.GD group of TSH is lower than healthy controls,GD1 TSH level below the GD2 group.P<0.05,compared with healthy controls,GD two subgroups of FT3 level was significantly higher,data statistical differences between groups,P<0.05,compared with those of GD2 group GD1 group of FT3 level is higher,data statistical differences between groups,P<0.05 compared with control group,GD1 group had a significantly higher FT4 levels,P<0.05.GD2 group FT4 level slightly lower than the control group,P>0.05,compared with those of GD2 group GD1 group had a significantly higher FT4 levels,P<0.05.The control group,the GD1 and GD2 group of serum adiponectin level and TSH is negative correlation,and FT4,FT3 is positive correlation,and there is no correlation between the baseline data.Conclusion Graves disease hyperthyroidism in treatment,adiponectin levels rise,after drug treatment,obtain relief,adiponectin increase cholesterol and FT4 influence,and the correlation between glucose metabolism index is not strong.After treatment,Graves disease in patients with hyperthyroidism adiponectin level is lower than normal group,the low and FT4 levels after treatment with a certain relevance.
