Influence of anti-depression therapy on inflammatory cytokines and quality of life in patients with acute coronary syndrome complicating depression
10.3969/j.issn.1673-4130.2017.10.028
- VernacularTitle:抗抑郁治疗对急性冠脉综合征伴抑郁患者炎性因子及生活质量的影响
- Author:
Yuanming WANG
;
De CHEN
;
Rui WANG
;
Ping WANG
;
Yue DAI
- Keywords:
acute coronary syndrome;
depression;
inflammatory cytokines;
quality of life
- From:
International Journal of Laboratory Medicine
2017;38(10):1365-1367
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of anti-depression therapy on inflammatory cytokines and quality of life(QOL) in patients with acute coronary syndrome(ACS) complicating depression.Methods Ninety-four patients with ACS complicating depression(HAMD total score ≥8) were randomly divided into the treatment group and control group,47 cases in each group.The control group was given the conventional drug therapy,pantoprazole 40 mg /d,on this basis the treatment group was given sertraline 50 mg/d.The treatment course in the two groups was 6 months.The change of HAMD score,inflammatory cytokines,QOL and incidence of adverse cardiovascular events were observed and compared between the two groups.Results The HAMD score after 3-,6-month treatment in the treatment group was significantly lower than that in the control group (P<0.05).The levels of inflammatory cytokines after treatment in the two groups were all reduced,while the IL-6 and TNF-α levels in the treatment group were lower than those in the control group (P<0.05);the scores of all dimensions and total scores of SAQ after 6-month treatment in the treatment group were significantly improved,and the anginal attack situation,treatment satisfaction degree and total score were significantly higher than those in the control group (P<0.05).During 12-month follow-up,the incidence rate of major and minor cardiovascular events,alimentary tract hemorrhage events and total events had no statistical difference between the two groups(P>0.05).Conclusion The antidepressant therapy is safe and effective for treating ACS patients,can effectively improve the depression emotion,inhibits inflammatory reaction,relieves somatic symptoms,and improves QOL.
