Analysis on feasibility of C14-urea breath test in diagnosis of child chronic cough
10.3969/j.issn.1673-4130.2017.10.029
- VernacularTitle:C14呼气试验应用于儿童慢性咳嗽诊断的可行性分析
- Author:
Xuebing ZHOU
;
Haisheng ZHANG
;
Wei LI
- Keywords:
C14 respiration detection;
children;
chronic cough;
diagnosis
- From:
International Journal of Laboratory Medicine
2017;38(10):1368-1369,1372
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility of C14-urea breath test in the diagnosis of child chronic cough.Methods One hundred and twenty children cases of chronic cough were collected as the research subjects and divided into the C14 group(adopting C14-urea breath test for diagnosis) and combined group(C14-urea breath test combined with routine diagnostic method) according to different diagnostic means,60 in each group.Then the positive diagnostic rate and effectiveness were analyzed and compared between the two diagnostic methods.Furthermore the ROC curve was adopted to evaluate its diagnostic value.Results The positive diagnosis rate in the C14 group was 76.67%,which was significantly lower than 95.00% in combined groups,the difference was statistically significant (P<0.001).The sensitivity and positive predictive value in the combined group were obviously higher than those in the C14 group (P<0.01),but there were no statistically significant differences in specificity and negative predictive value between the two methods (P>0.05).The expression levels of serum hs-CRP and IL-6 in the C14 group were significantly higher than those in the combined group,but the expression level of IL-10 was obviously lower than that of the combined group (P<0.05).The AUC in the ROC curve of combined group was significantly higher than that of the C14 group(P<0.05).Conclusion The C14-urea breath test can serve as a supplementary diagnosis means in child chronic cough,and its combining with the routine diagnosis method can significantly increase the diagnosis effectiveness.
