Optimization of Extraction Process of Yunpitongbian Decoction by Response Surface Methodology
- VernacularTitle:响应面法优选运脾通便合剂的提取工艺
- Author:
Kaiping ZOU
;
Haiou ZHU
;
Pingping LIU
;
Shun LIU
- Keywords:
Yunpitongbian decoction;
Hesperidin;
Atractylenolide Ⅲ;
Response surface methodology
- From:
China Pharmacist
2017;20(5):777-780
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the extraction process of Yunpitongbian decoction.Methods: With the extraction yield and the contents of hesperidin and atractylenolide Ⅲ as the comprehensive evaluation indices, and based on the results of single factor tests, Box-Behnken response surface methodology was used to optimize the extraction process with the extraction duration, extraction times and liquid-solid ratio as the independent variables.Results: The optimum processing conditions were as follows: extracted three times with 15-fold amount of solvent and extraction time of 66 min.The measured value of comprehensive score was 1.198 40, which was close to the predicted value of 1.204 78.Conclusion: The optimized extraction process of Yunpitongbian decoction is simple and feasible with good predictability.
