Mutagenesis of Thuja Essential Oil
- VernacularTitle:崖柏精油致突变作用研究
- Author:
Lu TANG
;
Jin PENG
;
Yan XIAO
;
Yang CHEN
;
Meihua BAO
- Keywords:
Thuja essential oil;
Genetic toxicity;
AMES;
Micronucleus test
- From:
China Pharmacist
2017;20(5):795-797
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the genetic toxicity of Thuja essential oil by salmonella reversion test (AMES test) and mammal micronucleus test.Methods: TA97, TA98, TA100 and TA102 were used in AMES test to evaluate the mutagenesis of Thuja essential oil.Mouse bone marrow micronucleus test was conducted to assess the chromosome toxicity of the drug.Results: Both in S9 present and absent situations, the numbers of reverse mutation of Thuja essential oil at different doses for the four strains were all less than 1-fold of that of solvent control, and the difference had no statistical significance (P>0.05), suggesting negative mutation.The micronucleus test indicated that Thuja essential oil had no influence on the rate of mouse bone marrow micronucleus (P>0.05).Conclusion: Thuja essential oil shows no obvious genetic toxicity.
