Extraction Optimization of Total Flavonoids from Oxytropis Falcata Bunge by Central Composite Design-response Surface Methodology
- VernacularTitle:星点设计-效应面法优化镰形棘豆总黄酮的提取工艺
- Author:
Qiping ZENG
;
Yihong WANG
;
Xiaohui CAI
;
Lina YANG
;
Jinshan CHEN
- Keywords:
Oxytropis falcate Bunge;
Total flavonoids;
Central composite design-response surface methodology;
Extraction technology
- From:
China Pharmacist
2017;20(5):801-804
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the extraction process of total flavonoids from Oxytropis falcata bunge.Methods: With the content of total flavonoids as the index,and based on the results of single factor tests, central composite design-response surface methodology was adopted to optimize the extraction technology with the solvent amount, ethanol concentration and extraction time as the factors.Results: The optimal extraction conditions were as follows: extracted twice with 20-fold amount of 66% ethanol, and 84 minute per time.Under the above conditions, the extraction rate of total flavonoids was up to 23.21 mg·g-1.Conclusion: The central composite design-response surface methodology is convenient and highly predictive for the extraction optimization of total flavonoids from oxytropis falcata bunge.
