Preparation and in vitro Drug Release of Daptomycin Liposomes
- VernacularTitle:达托霉素脂质体的制备和体外释放度考察
- Author:
Dengshan ZHANG
;
Liucheng LIU
- Keywords:
Daptomycin liposomes;
Preparation;
Characterization;
In vitro drug release
- From:
China Pharmacist
2017;20(5):827-832
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare daptomycin liposomes and investigate the in vitro drug release.Methods: Daptomycin liposomes were prepared by an active loading method.The distribution of particle size and zeta potential of liposomes were determined by a laser particle size analyzer.The encapsulation efficiency and in vitro drug release were determined by HPLC.Results: The particle size of daptomycin liposomes was 109.5 nm, the heterogeneous dispersion coefficient was 0.042 and the zeta potential was-6.48 mV.The entrapment efficiency determined by gel column and centrifugation was 50.8% and 50.3%, respectively.The result of in vitro drug release showed that daptomycin liposomes had a good sustained-release effect when compared with daptomycin for injection.Conclusion: Daptomycin liposomes have uniform particle size, which can release drug slowly to reduce administration frequency.
