Effects of Exenatide on Body Weight, Blood Glucose, Blood Lipids and Proteinuria in Obese and Overweight Young and Middle-aged Patients with Type 2 Diabetes
- VernacularTitle:艾塞那肽对肥胖及超重的中青年2型糖尿病患者体质量、血糖、血脂及蛋白尿的影响
- Author:
Wei ZHU
;
Xiuying GAO
;
Caihong GUO
;
Baoying GUO
;
Xin LU
;
Ruiqing WANG
- Keywords:
Exenatide;
Obesity;
Overweight;
Type 2 diabetes
- From:
China Pharmacist
2017;20(5):842-845
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of exenatide on body weight, blood glucose, blood lipids and proteinuria in obese and overweight young and middle-aged patients with type 2 diabetes to provide reference for better controlling the macro-vascular and micro-vascular complications in the patients.Methods: Totally 60 obese and overweight young and middle-aged patients with poorly controlled type 2 diabetes were chosen and randomly divided into exenatide group and novolin N group with 30 ones in each.The patients maintained the previous oral hypoglycemic drugs, and exenatide group was treated with exenatide, Novolin N group was treated with protamine biosynthetie human insulin(NovolinN), and the treatment course was 3 months.The body weight, BMI, fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2hPG), glycated hemoglobin (HbA1C), fasting C-peptide (FCP), 2-hour postprandial C-peptide (2hCP), blood lipids, plasma homocysteine (HCY) and urine microalbumin (UMA) were compared before and after the treatment.Results: After 3 month treatment,the FPG,zhpG and HbAlc were significantly decreased both in exenatide group and NwoCinN group(P<0.05),and were no significant differences.were found in these parameters between the two groups(P>0.05).In exenatide group, the levels of FCP and 2hCP were higher than those before the treatment (P<0.05), and the body weight, BMI, TG and UMA were significantly lower than those before the treatment (P<0.05).However, in Novolin N group, all the above-mentioned indices were not significantly changed after the treatment (P>0.05).Conclusion: Exenatide can effectively control blood glucose, improve β-cell function, reduce body weight, lower blood lipids and decrease urine protein.
