Stability of Icariin, 2,3,5,4'-Tetrahydroxy-stilbene-2-O-β-D-glucoside and Hyperoside in Huangmai Mixture
- VernacularTitle:黄麦合剂中淫羊藿苷、二苯乙烯苷、金丝桃苷的稳定性考察
- Author:
Jun LIN
;
Xiaodong YAO
;
Linghong XIA
;
Guanqin JIN
- Keywords:
Huangmai mixture;
Astrogaloside IV;
Morindae officinalis Radix;
Icariin;
2;
3;
5;
4'-Tetrahydroxy-stilbene-2-O-β-D-glucoside;
Hyperoside;
Accelerated testing;
Long-term testing;
Chinese herbal compound formula
- From:
China Pharmacist
2017;20(5):916-920
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the stability of icariin, 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside and hyperoside in Huangmai mixture.Methods: TLC was used to identify astrogaloside IV and Morindae officinalis Radix, and HPLC was used to determine the contents of icariin, 2,3,5,4'-retrahydroxy-stilbene-2-O-β-D-glucoside and hyperoside.The stability of Huangmai mixture under the conditions of accelerated testing and long-term testing was assessed.Results: Astrogaloside IV, Morindae officinalis Radix and icariin showed good stability during the accelerated testing and long-term testing.The contents of 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside and hyperoside declined quickly during the stability testing.Conclusion: Hyperoside and 2,3,5,4'-retrahydroxy-stilbene-2-O-β-D-glucoside are unstable in Huangmai mixture.A novel solid dosage form of Huangmai should be developed to obtain better stability.
