Determination of Nipagin Esters and Metronidazole Illegally Added to Chitosan Medical Devices
- VernacularTitle:壳聚糖类医疗器械非法添加尼泊金酯类及甲硝唑的测定
- Author:
Lin PENG
;
Bin LIAO
;
Haiping HUANG
;
Min YAN
;
Pang LIU
- Keywords:
Chitosan;
Medical devices;
Nipagin esters;
Metronidazole
- From:
China Pharmacist
2017;20(5):924-927
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine bacteriostatic drugs nipagin esters and metronidazole illegally added to chitosan medical devices.Methods: An HPLC method was used with a ZORBAX Eclipse XDB-C18(250 mm×4.6 mm, 5 μm)column.The mobile phase was water and acetonitrile(65∶35).The flow rate was 1.0 ml·min-1.The detection wavelength was 254 nm.The column temperature was 35℃ and the injection volume was 10 μl.Results: Nipagin esters were detected out in chitosan suppositories and gel.Metronidazole was detected out in chitosan lotion.Conclusion: The method is simple and fast, which has guiding significance for further comprehensive studies of bacteriostatic drugs illegally added to chitosan medical devices.
