Content Determination of Ferric Iron and Ferrous Iron in Ferrous Succinate Tablets by Ion Chromatography-Inductively Coupled Plasma Mass Spectrometry
- VernacularTitle:离子色谱-电感耦合等离子体质谱联用测定琥珀酸亚铁片中三价铁和二价铁含量
- Author:
Yagang FAN
;
Ying WANG
;
Wensong ZUO
- Keywords:
Ferrous succinate tablets;
Content determination;
IC-ICP-MS
- From:
China Pharmacist
2017;20(5):956-958
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish a content determination method for ferric iron and ferrous iron in ferrous succinate tablets.Methods: Using a Dionex RFICTM protection column (4 mm×50 mm)and a Dionex RFICM Ion PacRCS5A analytical column (4 mm×250 mm), the eluent solution consisted of 7 mmol·L-1 dipicolinic acid, 66 mmol·L-1 potassium hydroxide, 5.6 mmol·L-1 potassium phosphate monobasic and 74 mmol·L-1 formic acid.The flow rate was 1.5 ml·min-1, the column temperature was 30.0℃ and the injection volume was 1.3 μl.Results: Fe3+ showed good linearity within the range of 0.5-15 μg·ml-1(r=1.000 0), Fe2+ showed good linearity within the range of 25-200 μg·ml-1(r=1.000 0), and the average recovery was 103.6%(RSD=2.7%, n=9)and 98.3%(RSD=1.9%, n=9), respectively.Conclusion: The method is simple, reliable and accurate, and can be used for the determination of Fe3+and Fe2+ in ferrous succinate tablets.
