Lung cancer complicated with syndrome of inappropriate secretion of antidiuretic hormone:A report of 2 cases and literature review

VernacularTitle:肺癌并发抗利尿激素不适当分泌综合征2例报告及文献复习
Author: Yan XIAO ; Huan WANG ; Shumin WANG ; Ying GAO
Keywords: syndrome of inappropriate secretion of antidiuretic hormone; hyponatremia; lung neoplasms; tolvaptan
From: Journal of Jilin University(Medicine Edition) 2017;43(3):643-645
CountryChina
Language:Chinese
Abstract: Objective:To analyze the clinical materials of 2 patients with lung cancer complicated with syndrome of inappropriate secretion of antidiuretic hormone (SIADH),and to improve the clinical awareness and management.Methods:One patient was treated with lung cancer chemotherapy alone for 7 courses.The other patient received the strictly limited for liquid intake and tolvaptan by oral against hyponatremia without chemotherapy.Results:With the relapsing and advancing of lung cancer,the hyponatremia and its relevant symptoms of the first patient were poorly relieved.While the level of serum sodium of the second patient returned to the normal level 3 d after administration of tolvaptan.Conclusion:About one-third of the patients with hyponatremia have SIADH.The etiological treatment and symptomatic therapy of hyponatremia should be given to the patients in clinical treatment.