The effect of different HAART regimens on liver function and HIV load of HIV infected children with HCV co-infection

VernacularTitle:不同HAART方案对HIV合并HCV感染患儿肝功能和HIV载量的影响
Author: Heping RAO ; Changzhong JIN ; Xiangning JIN ; Meixin FANG ; Wei WANG ; Weili LU
Keywords: HIV; hepatitis C; viral load; antiretroviral therapy; highly active; liver function
From: Chongqing Medicine 2017;46(15):2045-2047
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of different HAART regimens on liver function,viral load and CD4+T cells of HIV infected children with HCV co-infection.Methods A total of 40 patients were divided into 4 groups:13 cases in AZT+3TC+NVP group(group A),16 cases in AZT+3TC+EFV group(group B),5 cases in D4T+3TC+EFV group(group C)and 6 cases in D4T+3TC+NVP group(group D).Liver function,viral load and CD4+T cells of patients in 4 groups were compared between before and after HAART.Results Eight patients(20％)had abnormal liver function before HAART treatment,and all of them had 1 level of liver damage.After receiving HAART,levels of ALT and AST were increased in group A and B(P<0.01);AST levels were increased in group C(P<0.01).CD4+T counts were all increased and HIV viral loads were decreased in 4 groups(P<0.01).There was no significant difference in RNA HCV load before and after HAART treatment(P>0.05).Conclusion Different HAART regimens can increase the liver damage in HIV infected children co-infected with HCV,but have little effect on the treatment efficiency of HAART regimens.