Expression of interleukin-33 and vascular endothelial growth factor-C in gastric cancer and its clinical significance
10.3969/j.issn.1671-8348.2017.15.014
- VernacularTitle:白细胞介素-33和血管内皮生长因子C在胃癌中的表达及临床意义
- Author:
Bingxiang XIA
;
Fan LI
;
Jian XU
;
Zhenhua YUAN
;
Suwen ZHENG
;
Yewei ZHANG
- Keywords:
stomach neoplasms;
vascular endothelial growth factor C;
interleukins 33;
lymph node metastasis
- From:
Chongqing Medicine
2017;46(15):2056-2059,2062
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of interleukin-33(IL-33)and vascular endothelial growth factor C(VEGF-C)in gastric cancer tissues and serum,and to explore the relationship between these two indicators and gastric cancer lymph node metastasis.Methods The levels of IL-33 and VEGF-C in the tissues of gastric mucosa and serum were detected by immunohistochemical SP method and enzyme-linked immunosorbent assay(ELISA)in 98 patients with gastric cancer and 36 healthy subjects.Results The expression rates of IL-33 and VEGF-C in gastric cancer were 67.35％and 74.49％,which were significantly higher than the rates in normal gastric tissue(47.22％and 61.11％).The difference was statistically significant(P<0.01).The expression of IL-33 and VEGF-C was correlated with the degree of tumor differentiation,tissue infiltration,lymph node metastasis,distant metastasis and clinical stage(P<0.05).The positive rates of IL-33 and VEGF-C in gastric cancer lymph node metastasis group were higher than those in non-lymph node metastasis group(P<0.05).The serum concentrations of IL-33 and VEGF-C in patients with gastric cancer were(50.24±13.08)pg/mL and(210.73±58.35)pg/mL,respectively,which were higher than those in healthy control group(P<0.05);the expressions of serum concentration of IL-33 and VEGF-C in the cases with lymph node metastasis were higher than those without lymph node metastasis and the difference was statistically significant(P<0.05).Conclusion High levels of IL-33 in gastric carcinoma patients might induce the secretion of VEGF-C,promote lymph node metastasis,and be applied as an important index of the appraisal to the prognosis of gastric cancer.
