An association analysis between polymorphism of glutamate receptor 6 gene and impulsively aggressive behavior in patients with bipolar disorder
10.3760/cma.j.issn.1008-1372.2017.05.008
- VernacularTitle:谷氨酸受体6基因多态与双相障碍患者冲动攻击行为关联分析
- Author:
Wei HU
;
Shaohong ZOU
;
Zongfeng ZHAO
;
Gaiyu TONG
;
Yi ZHANG
- Keywords:
Receptors,glutamate/GE;
Polymorphism,single nucleotide;
Bipolar disorder/CO/GE;
Impulsive behavior/CO/GE;
Aggression
- From:
Journal of Chinese Physician
2017;19(5):664-666
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between impulsively aggressive behavior and rs6922753 single nucleotide polymorphism of glutamate receptor 6 (GluR6) gene in Xinjiang Uygur and Han patients with bipolar disorder.Methods The techniques of polymerase chain reaction (PCR) and DNA sequencing technique were conducted to detect rs6922753 single nucleotide polymorphism of GluR6 gene in 240 patients with bipolar disorder.The association between the polymorphisms and impulsively aggressive behavior was analyzed with SPSS 17.0 software.Results No statistical difference was observed between the impulsively aggressive behavior group and the no impulsively aggressive behavior group of Xinjiang Han and Uygur patients with bipolar disorder in the genotype and allele frequencies for the investigated rs6922753 polymorphisms (P ＞ 0.05).Conclusions No association was found between the impulsively aggressive behavior and rs6922753 single nucleotide polymorphism of GluR6 gene in Xinjiang Uygur and Han patients with bipolar disorder.
