Acitretin combined with total glucosides of peony for psoriasis:a Meta analysis
10.3969/j.issn.1671-8348.2017.15.024
- VernacularTitle:阿维A联合白芍总苷治疗银屑病的Meta分析
- Author:
Xiujuan HE
;
Aijun CHEN
- Keywords:
acitretin;
radix paeoniae alba;
psoriasis;
total glucosides of peony;
Meta-analysis
- From:
Chongqing Medicine
2017;46(15):2085-2088,2093
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and adverse reaction of acitretin combined with total glucosides of peony for patients with psoriasis.Methods Clinical controlled trials that compared acitretin with combination therapy of acitretin and total glucosides of peony for patients with psoriasis were searched in the Cochrane Library,PubMed,Embase and so on(from establishment to October 2016).All extractive data analysis was performed by Review Manage version 5.3 after the data was extracted and the quality was assessed according to the inclusion criteria.Results A total of 8 articles were included.The results of meta-analysis showed that the total effective rate[OR=3.15,95％CI(2.04,4.86),P<0.01] and the psoriasis area and severity index(PASI)score[WMD=-2.05,95％CI(-2.74,-1.36),P<0.05] of treatment group were better than those of control group.The incidence rates of cheilosis,dryness of eye,dryness and itch of skin,dysfunction of liver,and hyperlipemia in treatment group were lower than those in control group(P<0.05).However,the incidence of rhinorrhagia was no statistically significant difference between the two groups(P>0.05).Conclusion Acitretin combined with total glucosides of peony for patients with psoriasis can improve the clinical efficacy and reduce the incidence of adverse reaction.
