Efficacy of liraglutide in the treatment of nonalcoholic fatty liver disease:a Meta analysis

VernacularTitle:利拉鲁肽治疗非酒精性脂肪肝疗效的Meta分析
Author: Hong LI ; Shiyun PU ; Qinhui LIU ; Xin HUANG ; Jiangying KUANG ; Lei CHEN ; Jing SHEN ; Shihai CHENG ; Tong WU ; Yanping LI ; Li MO ; Wei JIANG ; Jinhan HE
Keywords: liver diseases; fatty liver; lipids; peptides; liraglutide; nonalcoholic fatty liver disease; Meta-analysis
From: Chongqing Medicine 2017;46(15):2098-2101
CountryChina
Language:Chinese
Abstract: Objective To evaluate the efficacy of liraglutide in the treatment of Nonalcoholic Fatty Liver Disease(NAFLD).Methods Randomized controlled trials(RCTs)that evaluated the efficacy of liraglutide for NAFLD treatment were searched in multiple databases,including Pubmed,EMBASE,the Cochrane library,CNKI,Wanfang database and VIP.Literature identification and data extraction were based on the inclusion and exclusion criteria.RevMan 5.3 software was used for Meta-analysis.Results A total of 7 RCTs with 500 patients of NAFLD were included.Improved liver histology,or improved the level of alanine aminotransferase[WMD=-25.32,95％CI(-37.22,-13.41),P<0.01] and aspartate aminotransferase[WMD=-24.56,95％CI(-35.10,-14.03),P<0.01] were seen in 12-48 weeks liraglutide treatment.However,liraglutide could not decreased the level of serum cholesterol[WMD=-14.38,95％CI(-48.95,-20.20),P=0.42] and triglyceride[WMD=-15.55,95％CI(-36.20,-5.10),P=0.14].Conclusion liraglutide has the therapeutic effect of NAFLD.