Expression and significance of ABCG2 and ALDH1 in malignant transformation of ovarian endometriosis
10.3969/j.issn.1671-8348.2017.14.013
- VernacularTitle:ABCG2和ALDH1在卵巢子宫内膜异位症恶变中的表达和影响研究
- Author:
Songping LIU
;
Xin TIAN
;
Jian WEN
;
Xinming YIN
- Keywords:
ovarian cysts;
endometriosis;
allergy and immunology;
stem cells;
ABCG2;
ALDH1
- From:
Chongqing Medicine
2017;46(14):1912-1914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of ABCG2 and ALDH1 in malignant transformation of ovarian endometriosis.Methods The protein expressions of ABCG2 and ALDH1 were detected with immunohistochemistry in 38 cases of malignant transformation of ovarian endometriosis(EMs malignant transformation group),35 cases of endometriosis(EMs group)and 30 cases of normal endometrium(control group).Results The positive rates of ABCG2 and ALDH1 expressions in EMs malignant transformation group were significantly higher than those in EMs group and control group(P<0.05).The expressions of ABCG2 and ALDH1 were significantly associated with the serum CA125 level,differentiation and clinical stage of malignant transformation of ovarian endometriosis (P<0.05),but were not related to the patient′s age,dysmenorrhea history and pathology type(P>0.05).There was no correlation between the expression of ABCG2 and ALDH1 in malignant transformation of ovarian endometriosis(P>0.05).Conclusion The expressions of ABCG2 and ALDH1 might be involved in malignant transformation of ovarian endometriosis.
