Relationship between serum uric acid level and cerebrovascular stenosis in acute ischemic stroke patients
10.3969/j.issn.1009-0126.2017.05.013
- VernacularTitle:血尿酸水平与脑梗死急性期脑血管狭窄的关系
- Author:
Huifeng CHEN
;
Dandan YANG
;
Yuanrong YAO
- Keywords:
uric acid;
brain infarction;
cerebrovascular disorders;
magnetic resonance angiography;
hypertension;
diabetes mellitus;
hyperlipidemias
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2017;19(5):503-506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between serum uric acid (UA) level and cerebrovascular stenosis in acute ischemic stroke (AIS) patients.Methods Five hundred and thirteen patients with AIS or old IS admitted to our hospital from April 2014 to April 2016 were divided into primary IS group (n=236),recurrent IS group (n=136),and old IS group (n=141).Venous blood samples were taken on admission for biochemical testing.The patients were further divided into serum UA≤255 μmol/L group (n=128),serum UA=256-312μmol/L group (n=129),serum UA=313-371 μmol/L group (n=129),and serum UA＞371 μmol/L group (n=127).Their cerebrovascular stenosis was assessed by CT angiography or magnetic resonance angiography after admission.Results The severity of cerebrovascular stenosis,hypertension,diabetes and hyperlipidemia was significantly different in primary IS group,recurrent IS group and old IS group (27.5％ vs 33.8％ vs 12.8％、24.2％ vs 28.7％ vs 46.8％、61.9％ vs 49.3％ vs 40.4％、71.6％ vs 61.8％ vs 46.8％,P=0.000).Logistic regression analysis showed that serum UA≤ 255 μmol/L was an independent risk factor for cerebrovascular stenosis (OR =2.787,95 ％CI:2.209-3.365,P=0.001).The risk of cerebrovascular stenosis decreased gradually with the elevated serum UA level.Conclusion Serum UA level is not directly related with recurrent IS.Low serum UA level is a risk factor for cerebrovascular stenosis in AIS.
