Effect of lifestyle intervention on indexes of patients with dyslipidemia: a meta-analysis
10.3760/cma.j.issn.0254-9026.2017.05.026
- VernacularTitle:生活方式干预对血脂异常患者血脂指标影响的Meta分析
- Author:
Qin WU
;
Xiaoxiao CHEN
;
Yaping DU
- Keywords:
Life style;
Dyslipidemia
- From:
Chinese Journal of Geriatrics
2017;36(5):583-588
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of lifestyle intervention on the indexes of patients with dyslipidemia.Methods CNKI,Wanfang Database,VIP,PubMed,Web of Science,EBSCO,EMbase,the Cochrane Library,Clinical Trials,MEDLINE were retrieved.The search terms included lifestyle intervention,lifestyle,diet,physical activity,dyslipidemia,hypercholesterolemia,lipid,low fat diet,plant sterols,low-glycemic index(GI)diets,mono-unsaturated fatty acids.Articles on randomized controlled trials(RCTs)to study the effect of lifestyle intervention on the indexes of patients with dyslipidemia were screened according to inclusion and exclusion criteria.Meta-analyses were conducted by using RevMan 5.3 software after extracting data.Results 19 articles were internalized,including 2 294 patients(intervention group,n=1,170)and(control group,n =1,124).According to the results of intervention group versus control group,total cholesterol of weighted mean difference(WMD)was (-0.61,95 ％CI.-0.84～-0.38,P＜0.01),triglyceride of WMD was(-0.28,95 ％ CI:-0.42～ 0.15),P＜0.01),low-density lipoprotein cholesterol of WMD was (-0.45,95 ％ CI:-0.72 ～ 0.18,P ＜0.01),(all P＜0.01),with significantly lower WMD in intervention group than in control group.The high-density lipoprotein cholesterol of WMD was (-0.05,95 ％ CI:-0.22 ～ 0.12,P =0.59),the difference was not significant.Conclusions Lifestyle intervention improves serum levels of total cholesterol,triglyceride and low-density lipoprotein cholesterol for dyslipidemia patients,but its effect on high-density lipoprotein cholesterol is not significant.
