Effect of TACE on the prognosis of patients with hepatocellular carcinoma after operation
10.3969/j.issn.1009-9905.2017.06.007
- VernacularTitle:TACE对肝癌患者术后疗效及预后的影响因素分析
- Author:
Yingfeng LI
;
Han JIANG
;
Tongzhi YIN
- Keywords:
Primary carcinoma of the liver;
Radical resection;
Transcatheter arterialchemoembolization;
Clinical efficacy;
Prognosis
- From:
Chinese Journal of Current Advances in General Surgery
2017;20(6):447-450
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the curative effect and prognostic factors of primary liver cancer(PHC) treated with radical resection combined with transcatheter arterial chemoembolization (TACE).Methods:A retrospective analysis was used to analyze the clinical data of 136 cases of PHC patients treated in Qianjiang Central Hospital of Hubei Province from January 2008 to January 2012,the 86 cases received radical resection and postoperative adjuvant TACE treatment of patients as the observation group,and the remaining 50 cases only with radical resection in the treatment of patients were selected as control group.After 6 months of treatment,the level of tumor markers Carcinoembryonic antigen(CEA),alpha fetoprotein(AFP),CA199 and alanine aminotransferase(ALT) in two groups were observed and compared.The survival status and prognostic factors of the two groups were compared.Results:After 6 months of treatment,the leve of tumor markers CEA,AFP,CA199 and ALT in the observation group were significantly lower than those in the control group(P＜0.05);The 1-year,2-year,and 3-year survival rate of the observation group were significantly higher than those in the control group;Univariate analysis showed that the differentiation degree,tumor size,lymph node metastasis,vascular tumor thrombus,CA199 concentration factors and the observation group patients (radical resection and postoperative adjuvant TACE) postoperative survival period (P＜0.05);Further multivariate analysis showed that the degree of differentiation,lymph node metastasis and CA199 concentration were the important factors influencing the prognosis of patients with TACE after radical resection (P＜0.05).Conclusion:Radical resection combined with TACE in the treatment of PHC has well clinical curative effect,which can effectively improve the postoperative long-term survival rate.Degree of differentiation,lymph node metastasis,and CA199 concentration are important factors impacting the radical resection operation adjuvant TACE prognosis.
