Application of hemostatic silk shielding on ulcers induced by endoscopic submucosal dissection

VernacularTitle:止血绫修复内镜黏膜下剥离术后创面的应用研究
Author: Zhong CHEN ; Yiling CAI ; Ming MA ; Zhongzheng HAN ; Qin ZHANG ; Junyao WANG ; Qinglin TANG ; Huayu ZHANG ; Mingqing ZHANG
Keywords: endoscopic submucosal dissection (ESD); animal models; hemostatic silk; the healing of the wound
From: China Journal of Endoscopy 2017;23(5):28-33
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical value of hemostatic silk in prevention of wound bleeding and wound healing after endoscopic submucosal dissection (ESD). Methods Experiment group: animal model was made by rabbit underwent ESD simulation in its' stomach and laying hemostatic silk on its' wound;control group: animal model was made by pig underwent ESD simulation in its' colon without any healing management. All the ulcers sites were endoscopically and pathologically examined to evaluate the hemorrhage and healing of the wound on 3 days, 1 week, 2 weeks and 4 weeks after the procedure. Results The blood loss in experiment group was significantly lower than that in control group. The wounds of all the experimental pigs underwent colon ESD successfully covered with hemostatic silk postoperatively. Endoscopic pathological examination shown better healing procedure in experiment group. No procedure-related adverse event occurred in both groups. Conclusions Hemostatic silk has potential application value in healing the wound after ESD demonstrated by animal experiment.