Effects of Midazolam Combined with Tramadol on Prognosis of Patients Underwent Tumor Resection in Gastrointestinal Surgery Department
10.6039/j.issn.1001-0408.2017.15.12
- VernacularTitle:咪达唑仑联合曲马多对实施胃肠外科肿瘤切除术患者预后的影响
- Author:
Dezhong ZHANG
;
Lili WANG
- Keywords:
Midazolam;
Tramadol;
Postoperative rehabilitation;
Gastrointestinal surgery department;
Tumor;
Hypostatic pneu-monia
- From:
China Pharmacy
2017;28(15):2057-2059
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of tramadol combined with midazolam on prognosis of patients underwent tumor resection in gastrointestinal surgery department. METHODS:In retrospective study,200 tumor patients of gastrointestinal sur-gery department were divided into observation group(100 cases)and control group(100 cases). Observation group was given Tra-madol hydrochloride tablet 100 mg,3 times a day+Midazolam injection 30 mg,added into 0.9% Sodium chloride injection 60 mL,via intravenous pump,2.5 mL/h,for consecutive 24 h,for consecutive 3 d. Control group was given Tramadol hydrochloride injection 100 mg,intramuscular injection,3 times a day,for 3 d. The hospitalization duration,postoperative ambulation time, sleep quality score,pain degree score,the occurrence of postoperative hypostatic pneumonia,and the incidence of adverse reactions in 2 groups were observed. RESULTS:The hospitalization duration and postoperative ambulation time of observation group were significantly shorter than those of control group;the sleep quality score of observation groups was significantly higher than that of control group;the severity of pain,the incidence of hypostatic pneumonia were significantly lower than control group,with statisti-cal significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). CONCLU-SIONS:Midazolam combined with tramadol can significantly reduce the postoperative pain of tumor patients in gastrointestinal tu-mor surgery department,shorten hospitalization time and postoperative ambulation time,improve the sleep quality of patients and reduce the incidence of hypostatic pneumonia with good safety.
