Evidence-based Review on Yanhuning Injection in the Treatment of Epidemic Mumps
10.6039/j.issn.1001-0408.2017.15.18
- VernacularTitle:炎琥宁注射剂治疗流行性腮腺炎疗效的循证评价
- Author:
Bo TIAN
;
Jianxin HU
;
Ruiyue HU
;
Zhiyou LI
- Keywords:
Essential medicine;
Supplement;
Evidence-based review;
Yanhuning injection;
Epidemic mumps;
Meta-analysis;
Efficacy
- From:
China Pharmacy
2017;28(15):2077-2081
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically evaluate therapeutic efficacy of Yanhuning injection in the treatment of epidemic mumps,explore valid way of evidence-based review,provide reference for the selection of new essential medicine list. METH-ODS:Retrieved from PubMed,CJFD,Wanfang database and VIP,randomized controlled trials(RCTs)about Yanhuning injection alone or combined with other positive drugs(trial group)vs. other positive drugs(control group)in the treatment of epidemic mumps. Meta-analysis was conducted by using Rev Man 5.3 statistical software after quality evaluation by modified Jadad scale. RE-SULTS:Totally 26 RCTs were included,involving 2613 patients. Results of Meta-analysis showed,overall response rate [OR=5.28,95%CI(3.92,7.11),P<0.001] of trial group was significantly higher than that of control group;defervescence time [MD=-1.97,95%CI(-2.83,-1.12),P<0.001],swelling disappearance time [MD=-2.05,95%CI(-2.53,-1.58),P<0.001] and pain disappearance time [MD=-1.39,95%CI(-2.02,-0.75),P<0.001] of trial group were significantly shorter than those of control group,there was statistical significance. CONCLUSIONS:Yanhuning injection has good curative effect for epidemic mumps,and can significantly shorten defervescence time,swelling disappearance time and pain disappearance time.
