Reactivation of human herpesvirus 6 and its clinical significance

VernacularTitle:人类疱疹病毒6型的再激活及其临床意义
Author: Kefu WU ; Guoguang ZHENG ; Xiaotong MA ; Yuhua SONG
Keywords: Herpesvirus 6; human; Hematopoietic stem cell transplantation; Lymphoma; Leukemia
From: Journal of Leukemia & Lymphoma 2017;26(5):257-260
CountryChina
Language:Chinese
Abstract: Human herpesvirus 6 (HHV-6) is recognized as a ubiquitous dsDNA virus in human with widespread cell tropism in vivo, which could induce lifelong latent infection and be reactivated in some immunocompromised individuals leading to serious diseases. With the increasing application of hematopoietic stem cell transplantation (HSCT), it is obvious that HHV-6 reactivation has a close relationship with several complications including encephalitis after transplantation. On the other hand, among about 1 % infected people, HHV-6 and subtelomeric region of cell chromosomes in the state of endogenous persistent infection play a part in activated virus infection. As the detection methods make a great progress in HHV-6 detection, clinical data reveals the relationship between HHV-6 reactivation and lots of chronic diseases, especially lymphoma, leukemia as well as some chronic hematopoietic and immunological diseases.