Acute myeloid leukemia with NPM-MLF1 fusion gene: report of one case and review of literature
- VernacularTitle:急性髓系白血病伴NPM-MLF1融合基因一例并文献复习
- Author:
Gangji ZHANG
;
Wei LI
;
Shaowei QIU
;
Shuning WEI
;
Kaiqi LIU
;
Yuntao LIU
;
Benfa GONG
;
Runxia GU
;
Xiaoyuan GONG
;
Bingcheng LIU
;
Chunlin ZHOU
;
Hui WEI
;
Ying WANG
;
Dong LIN
;
Yingchang MI
;
Jianxiang WANG
- Keywords: Leukemia; myeloid; acute; Gene fusion; Translocation; genetic; Prognosis
- From: Journal of Leukemia & Lymphoma 2017;26(5):283-286
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the characteristics of NPM-MLF1 fusion gene in acute myeloid leukemia (AML). Methods The data of one AML patient with NPM-MLF1 fusion gene was analyzed,and literatures were reviewed. Results A female patient was diagnosed as AML M6. In the course of the disease, 2 hematologic relapsed, and 2 recurrences were associated with NPM-MLF1 fusion gene positive. After inductive treatment, hematologic complete remission was achieved, and NPM-MLF1 fusion genes were all negative. Survival time surpassed 6 years when the chemotherapy was performed alone. Conclusion The incidence of NPM-MLF1 fusion gene in AML is low. It is necessary to collect more clinical data to judge whether an independent disease type or not.