Expression of programmed death 1/programmed death ligand 1 signaling pathway in lymphoma

VernacularTitle:程序性死亡受体1/程序性死亡受体配体1信号通路在淋巴瘤中的表达及研究进展
Author: Shanshan FAN
Keywords: Lymphoma; Programmed death 1; Signal transduction
From: Journal of Leukemia & Lymphoma 2017;26(5):317-320
CountryChina
Language:Chinese
Abstract: The latest study shows that the expression abnormalities of programmed death 1/programmed death ligand 1 (PD-1/PD-L1) signaling pathway in a variety of solid tumor tissues and cells are related to disease progression and poor prognosis, and directly involve in tumor immune escape, becoming the recent focus. With the further research, PD-1/PD-L1 signaling pathway in blood diseases, for example, in the development of lymphoma, is catching more attention gradually. The signaling pathway not only is associated significantly with malignancy, progression, recurrence of lymphoma and prognosis of patients, but probably becomes a new target for cancer immunotherapy. This paper summarizes the expression and research status of the biological characteristics and mechanism of PD-1/PD-L1 signaling pathway in lymphoma, in order to provide a new way for lymphoma treatment.