Wine drinking and epithelial ovarian cancer risk: a meta-analysis.
10.3802/jgo.2010.21.2.112
- Author:
Hee Seung KIM
1
;
Jae Weon KIM
;
Leo J SHOUTEN
;
Susanna C LARSSON
;
Hyun Hoon CHUNG
;
Yong Beom KIM
;
Woong JU
;
Noh Hyun PARK
;
Yong Sang SONG
;
Seung Cheol KIM
;
Soon Beom KANG
Author Information
1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. kjwksh@snu.ac.kr
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Wine;
Resveratrol;
Epithelial ovarian cancer
- MeSH:
Case-Control Studies;
Cohort Studies;
Drinking;
Female;
Humans;
Neoplasms, Glandular and Epithelial;
Ovarian Neoplasms;
Stilbenes;
Wine
- From:Journal of Gynecologic Oncology
2010;21(2):112-118
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Wine has been the focus in the prevention of epithelial ovarian cancer (EOC) development because resveratrol abundant in wine has anti-carcinogenic properties. However, epidemiologic results have been heterogenous in the chemopreventive effect of wine on the development of EOC. Thus, we performed a meta-analysis for comparing EOC risk between wine and never drinkers using previous related studies. METHODS: After extensive search of the literature between January 1986 and December 2008, we analyzed 10 studies (3 cohort and 7 case control studies) with 135,871 women, who included 65,578 of wine and 70,293 of never drinkers. RESULTS: In all studies, there was no significant difference in EOC risk between wine and never drinkers (odds ratio [OR], 1.13; 95% confidence interval [CI], 0.92 to 1.38; random effects). When we performed re-analysis according to the study design, 3 cohort and 7 case control studies showed that there were also no significant differences in EOC risk between wine and never drinkers, respectively (OR, 1.44 and 1.04; 95% CI, 0.74 and 2.82 and 0.88 to 1.22; random effects). In sub-analyses using 2 case-control studies, EOC risk was not different between former and never drinkers (OR, 1.12; 95% CI, 0.87 to 1.44; fixed effect), and between current and former drinkers (OR, 0.74; 95% CI, 0.41 to 1.34; random effects). CONCLUSION: Although resveratrol, abundantly found in wine, is a promising naturally occurring compound with chemopreventive properties on EOC in preclinical studies, this meta-analysis suggests the epidemiologic evidence shows no association between wine drinking and EOC risk.
