Progress of discoidin domain receptor 2 in tumors
10.3760/cma.j.issn.1006-9801.2017.05.018
- VernacularTitle:盘状结构域受体2在肿瘤中的研究进展
- Author:
Liqun XU
;
Zhiqiang MA
;
Dong LIU
;
Chongxi FAN
;
Shouyin DI
- Keywords:
Neoplasms;
Cell proliferation;
Neoplasm invasiveness;
Discoidin domain receptor 2
- From:
Cancer Research and Clinic
2017;29(5):357-360
- CountryChina
- Language:Chinese
-
Abstract:
Discoidin domain receptor 2 (DDR2), a tyrosine kinase receptor belonging to DDRs family, is associated with progression of various cancers. Studies have indicated that DDR2 expression is upregulated in various cancer tissues, which could promote tumors proliferation, invasion, and metastases. Furthermore, patients with high DDR2 expression showed poor 5-year overall survival rate. In addition, DDR2 point mutation can enhance the sensitivity of tumor cells to small molecule tyrosine kinase inhibitor dasatinib, which suggests that DDR2 mutation may be a promising target for cancer therapy.
