Yanru HU; Xiaoli Liu; Decai Qiao

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"The modulating effect of 5-HT1B and D1DR receptors in neurons within ""SNr/GPi-VL-SMA"" pathway on exercise induced fatigue"

VernacularTitle:“黑质/苍白球-丘脑-皮质”通路5-羟色胺1B受体及多巴胺1型受体在大鼠运动疲劳调控中的作用
Author: Yanru HU ; Xiaoli LIU ; Decai QIAO
Keywords: "rat; exhausting exercise; ""SNr/GPi-VL-SMA"" pathway; 5-HT1B; D1DR"
From: Chinese Journal of Rehabilitation Medicine 2017;32(5):501-508
CountryChina
Language:Chinese
Abstract: Objective:To observe the changes of 5-HT1B and D1DR expression in nucleus of SNr/GPi-VL-SMA pathway in pre and post-exhaustive exercise,and investigate the central mechanism of SNr/GPi-VL-SMA pathway modulating the occurrence and development of exercise-induced fatigue.Method:Twenty-four male Wistar rats were randomly divided into control group (CG),immediately after exhaustion group (EG),and 90min after recovery group (RG),each consists of 8 rats.The expression level of 5-HT1B and D1DR receptors in each group were observed with the immunohistochemistry technique.Result:Compared with CG,the positive cell area/scanning area value (R value) and the average optical density value (AOD value) of 5-HT1B receptor in SNr and GPi of the EG and RG rats both decreased significantly (P ＜ 0.05),while the R value and AOD value of D1DR both increased significantly(P＜ 0.05).The R value and AOD value of 5-HT1B receptor in VL of EG and RG rats increased significantly(P＜0.05,P＜0.01).In SMA,the R value and AOD value of 5-HT1B receptor of EG and RG rats increased significantly (P＜ 0.05),while,the R value and AOD value of D1DR receptor decreased significantly (P ＜ 0.05).Conclusion:Changes of 5-HT1B receptor and D1DR receptor expression in the nuclei of ‘SNr/GPi-VL-SMA'pathway caused the changes of the neurotransmitters release,thus affecting the excitability of the electrical activity of neurons,this might be one of the important ways for ‘SNr/GPi-VL-SMA'pathway modulating the exercise-induced fatigue and exercise performance.