Longitudinal layer-specific strain technology in evaluation on left ventricular systolic function of breast carcinoma patients treated with anthracyclines
10.13929/j.1003-3289.201610122
- VernacularTitle:纵向分层应变技术评估蒽环类药物化疗后乳腺癌患者左心收缩功能
- Author:
Yong MA
;
Jie JIN
;
Yong CHEN
;
Fei YANG
- Keywords:
Breast neoplasms;
Chemotherapy,adjuvant;
Echocardiography
- From:Chinese Journal of Medical Imaging Technology
2017;33(5):708-712
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate left ventricular global longitudinal strain in endocardium,middle myocardium and epi cardium of patients with breast carcinoma treated with anthracyclines by two-dimensional layered strain technology.Methods Totally 20 breast cancer patients after surgery without chemotherapy (control group) and 32 breast cancer patients who were treated with anthracycline-based chemotherapy were enrolled.The patients treated with chemotherapy were performed transthoracic echocardiography 3 months and 5 months after chemotherapy.Global longitudinal strain (GLS) and each segment (apex,basis and media section) strain in 3 myocardial layers (endocardium,middle myocardium and epicardium) were measured by EchoPAC software.Results Compared with control group,with the extension of chemotherapy cycle,GLS of 3 myocardial layers reduced in breast carcinoma patients treated with anthracyclines (all P＜0.05),but left ventricular ejection fraction (LVEF) had no statistical difference (P＞0.05).Compared with control group,each layer of each segment of longitudinal strain decreased in breast carcinoma patients treated with anthracyclines (all P＜0.05),except the apex section.Conclusion Longitudinal layer-specific strain technology can accurate assess whole and local systolic function of 3 myocardial layers of left ventricular,which can provide a new method for judging myocardial damage.
