Quantitative Assessment of Brain Damage in Acute Phase Carbon Monoxide Poisoning Using Intravoxel Incoherent Motion Imaging
10.3969/j.issn.1005-5185.2017.03.007
- VernacularTitle:基于体素内不相干运动成像定量评估CO中毒急性期脑损伤程度的初步研究
- Author:
Yanli ZHANG
;
Tianhong WANG
;
Xiaoxue TIAN
;
Chaoning ZHOU
;
Zhaodong LIU
;
Shaoyu WANG
;
Junqiang LEI
- Keywords:
Brain injuries;
Acute disease;
Carbon monoxide poisoning;
Magnetic resonance imaging;
Intravoxel incoherent motion
- From:
Chinese Journal of Medical Imaging
2017;25(3):185-189,195
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To quantitatively evaluate the severity of brain damage in the acute phase of CO poisoning using intravoxel incoherent motion imaging.Materials and Methods MRI scans were performed in 26 patients with CO intoxication of acute stage and 18 healthy controls with matched age and gender.The difference of D value,D* value and f value in different ROIs between the poisoning and the control groups were compared,and the best cut-off values were determined.The correlation between the consciousness state and the D value as well as f value in the vulnerable area of the brain (globus pallidus) was analyzed.Results Compared with control group,the D and F value of the poisoning group were decreased in multiple ROIs,of which statistical significance was observed in the f values in the centrum semiovale,globus pallidus and thalamus,and the D values in the centrum semiovale,lateral ventricle,globus pallidus and corpus callosum splenium (P＜0.05).The best cut-off value,sensitivity and specificity were as follows:fcs=51％,77％,73％;fga=61％,77％,83％;ft=80％,85％,64％;D,=0.69×10-3 mm2/s,85％,83％;Dlv=0.65× 10-3 mm2/s,73％,89％;Dga=0.68× 10-3 mm2/s,62％,83％;Dccs=0.70× 10-3mm2/s,81％,89％.The disturbance of consciousness was positively correlated with decrease of D value and f value (rD=0.828,rf=0.745,P＜0.05).Conclusion The D and f values of intravoxel incoherent motion imaging can quantitatively evaluate the brain damage severity in acute CO poisoning.
