Efficacy and Safety of Combination of Yinxin Damo Injection and Low Molecular Heparin on Deep Venous Thrombosis in Orthopedics Operation: A Meta-analysis
10.3870/j.issn.1004-0781.2017.04.018
- VernacularTitle:银杏达莫注射液联合低分子肝素预防骨科大手术后深静脉血栓形成的Meta分析
- Author:
Jinlong XU
;
Lili YAO
;
Jinling WANG
;
Lu YU
;
Ming ZHANG
;
Weicheng MA
- Keywords:
Yinxing Damo injection;
Low molecular heparin;
Operation,orthopedics;
Thrombosis,deep venous;
Meta analysis
- From:
Herald of Medicine
2017;36(4):429-433
- CountryChina
- Language:Chinese
-
Abstract:
Objective Evaluation of efficacy and safety of combination of Yinxin Damo injection and low molecular heparin for deep venous thrombosis (DVT) in orthopedics operation.Methods Randomized controlled trials of combination of Yinxin Damo injection and low molecular heparin intervention study of DVT in orthopedics operation were searched from the Cochrane Library,clinicaltrials,gov,PubMed,EMBASE,CNKI,Wanfang database,VIP database,and Chinese biomedical database (CBM).According to the Cochrane Handbook 5.1,Meta analysis was performed by Revman 5.3 software.Results A total of 4 studies included 358 patients.The results of Meta-analysis showed that,compared with control group,incidence of DVT was significantly reduced (P =0.01),value of D-D significantly decreased (P ＜0.000 01) and value of PT increased (P =0.04),and increased value of APTT (P =0.07) in combined group.Heterogeneous sources of PT and APTT were analyzed,and the results after excluding literature 7,as compared with the control group,APTT and PT were significantly increased in combined group (P ＜ 0.000 1).Conclusion Based on the current clinical evidence,combination of Yinxin Damo injection and low molecular heparin treatment for DVT of orthopedics operation patients is effective and safe,but there is certain heterogeneity between the studies,therefore it is necessary to design a randomized controlled trial of high quality,large scale and multicenter to research.
