Pharmaceutical Care on Anti-infection Therapy of Patients with Augmented Renal Clearance
10.3870/j.issn.1004-0781.2017.04.020
- VernacularTitle:肾功能亢进患者抗感染治疗的药学监护
- Author:
Lian TANG
;
Qi DING
;
Fuli ZHAO
;
Gang WU
;
Guangxiang CHEN
;
Erning SHANG
- Keywords:
Vancomycin;
Augmented renal clearance;
Clinical pharmacist;
Pharmaceutical intervention
- From:
Herald of Medicine
2017;36(4):439-441
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of clinical pharmacist in anti-infection therapy for patients with augmented renal clearance (ARC).Methods A case with multi-site severe infection after traffic accident was treated with anti-infection therapy.According to the characteristics of infection and pharmacokinetics,clinical pharmacist discussed the intervention by clinical pharmacist in terms of formulating anti-infection program and adjustment of individual dose.Results After consultation and evaluation by clinical pharmacist,the patient was diagnosed as ARC.According to pharmacokinetics characteristics reported by literature,vancomycin was adjusted to 1 g (once per 8 h).Based on detection result of pathogenic bacteria,meropenem was replaced by cefoperazone/sulbactam,and the dose was increased to 3 g (once per 6 h).And then,vancomycin concentration was detected again,and it reached ＞ 10 μg· mL-1;pathogenic bacteria culture result was negative.This patient obtained good therapeutic effect.Conclusion Clinical pharmacist could assist physician on anti-infection treatment and dose adjustment of ARC patient,and improve ARC patient's therapeutic effect.
