Interaction of GNβ3 gene polymorphisms and environmental factors in susceptibility to major depressive disorder
10.3760/cma.j.issn.1674-6554.2017.04.001
- VernacularTitle:G蛋白β3亚单位基因多态性与环境因素在抑郁症中的交互作用
- Author:
Dong QI
;
Xiaohui QIU
;
Yanjie YANG
;
Jiarun YANG
;
Jingsong MA
;
Jian ZHANG
;
Mingzhe ZHAO
;
Lin WANG
;
Zhengxue QIAO
;
Xiuxian YANG
- Keywords:
Depression;
GNβ3 gene;
Single nucleotide polymorphism;
Environmental factor;
Interaction
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2017;26(4):289-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between GNβ3 gene and depression,and to investigate the interaction of gene-environment(negative life events and childhood trauma) and potential possible pathogenesis of depression.Methods The sample of peripheral blood was collected from Chinese Northern patients(n=500) and controls(n=500).Snapshot technique was used to detect the genotype frequency and allele frequency of GNβ3 rs5443 polymorphism in cases and controls.The genotype and allele frequencies were analyzed by Chi-square test,the interactions of gene-environment were analyzed by Logistic regression.Results GNβ3 rs5443 genotype and allele frequencies were observed between patients and controls (x2 =20.249,P＜0.01;x2 =4.803,P＜0.05).There were genotype CC 102 and 158,genotype CT 280 and 217,genotype TT 118 and 125;allele C 484 and 533,allele T 516 and 467 between patients and controls,respectively.Logistic regression analysis showed that the interaction between rs5443 T+ and negative life events was associated with depression (P＜0.05,OR=1.957).In addition,individual carrying rs5443T+ genotypes and negative life events could increase risk of depression.Conclusion GNβ3 rs5443 is a possible susceptibility gene of depression.The interaction between rs5443 and negative life events is associated with depression.
