Resting-state fMRI study of adolescents with conduct disorder: an ALFF analysis
10.3760/cma.j.issn.1674-6554.2017.04.006
- VernacularTitle:品行障碍青少年静息态fMRI低频振幅研究
- Author:
Qiong WU
;
Xiaocui ZHANG
;
Daifeng DONG
;
Shuqiao YAO
- Keywords:
Conduct disorder;
Resting-state fMRI;
Amplitude of low-frequency fluctuation;
Adolescents
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2017;26(4):316-320
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the functional characteristic of adolescents with conduct disorder (CD) in the resting state.Methods Resting-sate fMRI (rs-fMRI) scans were administered to 28 male adolescents with CD and 28 age-,gender-and IQ-matched healthy controls (HCs).The rs-fMRI data were subjected to amplitude of low-frequency fluctuation (ALFF) analysis and ALFF values were compared between the two groups.Additionally,the region ROIs showed significant difference and correlation analysis was conducted between ALFF in each ROI and Barratt's scores.Results ① Compared to HCs,the CD group showed decreased ALFF (P＜0.005) bilaterally in the superior frontal gyrus,right middle frontal gyrus,right posterior cingulate gyrus,right inferior parietal lobule (MNI coordinates:-21,48,27;21,24,48;36,24,33 6,-36,39;48,-45,57 respectively) as well as increased ALFF (P＜O.005) in the left thalamus and left lingual gyrus (MNI coordinates:-15,-27,-3;-18,-87,-12 respectively).② There was no significant correlation between ALFF and Barratt's scores in ROIs.Conclusion The results suggest that CD is associated with abnormal intrinsic brain activity,mainly in frontal-parietal-occipital-limbic cortices,which is related to emotional and cognitive processing and behavioral functions.
