Association between NT-proBNP and elevated nocturnal blood pressure in male elderly primary hypertension patients
10.3969/j.issn.1009-0126.2017.08.013
- VernacularTitle:N末端前体脑钠肽与老年男性原发性高血压夜间血压升高的相关性研究
- Author:
Yuqing SUN
;
Leiming LUO
- Keywords:
hypertension;
natriuretic peptide,brain;
circadian rhythm;
blood pressure;
risk factors
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2017;19(8):833-836
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association between NT-proBNP and elevated nocturnal blood pressure in male elderly primary hypertension patients.Methods Five hundred and ninety male elderly primary hypertension patients,admitted to our hospital from January 2009 to December 2012,were divided into non dipper hypertensivon group (n=418) and anti-dipper hypertension group (n =172).Their clinical data,laboratory test parameters and ambulatory ECG findings were recorded.Results The age was older,the serum levels of creatinine,HbAlc and NT-proBNP were higher in anti-dipper hypertension group than in non-dipper hypertensivon group (81.47± 9.25 years vs 77.81±11.10 years,P=0.000;113.18±99.70 μmol/L vs 93.35±84.49 μmol/L,P=0.017;7.34％±8.35％ vs 6.37％±1.05％,P=0.001;551.16±991.72 ng/L vs 355.12±934.89 ng/L,P=0.009).Multivariate regression analysis showed that average day systolic blood pressure was independently associated with NT-proBNP (P=0.004).Conclusion The loss of rhythmia is more noticeable and the target organ damage is more serious in anti-dipper hypertension patients than in non-dipper hypertensivon patients.The serum NT-proBNP level plays a certain role in regulating blood pressure.
