Diagnostic value of serum PLA2R antibody detection for idiopathic membranous nephropathy: A meta-analysis
10.13602/j.cnki.jcls.2017.07.18
- VernacularTitle:血清抗PLA2R抗体检测对特发性膜性肾病诊断效能的meta分析
- Author:
Mingjian LIAN
;
Rong LU
;
Jiaqin ZHANG
;
Guolin HONG
- Keywords:
PLA2R antibody;
idiopathic membranous nephropathy;
diagnostic value;
meta analysis
- From:
Chinese Journal of Clinical Laboratory Science
2017;35(7):545-549
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of serum M-type phospholipase A2 receptor(PLA2R) antibody detection for the diagnosis of idiopathic membranous nephropathy(IMN) by meta analysis.Methods By searching the databases of PubMed,Emabse,Wanfang and CNKI from inception to May,2017,all the literatures referred to serum PLA2R antibody for the diagnosis of IMN in both English and Chinese were reviewed and selected according to the inclusion and exclusion criteria.QUADAS was used to assess the quality of eligible studies.Meta-disc 1.4 was used to analyze heterogeneity and pooled effectsize and Stata 12.0 was used to analyze publication bias.Results A total of 20 studies with high quality were included.Heterogeneity test indicated there was no threshold effect.The pooled sensitivity was 0.69 (95 ％ CI:0.67 to 0.72),the pooled specificity was 0.97 (95 ％ CI:0.96 to 0.98) and the summary area under curve was 0.880.Sensitivity analysis indicated that the result was stable.Deek's funnel plot indicated there was no publication bias.Conclusion The sensitivity of detection of serum PLA2R antibody was acceptable for the diagnosis of IMN with high specificity,so more attention on PLA2R antibody should be paid in the clinical practice.
