Multiple lipid derived cytokines areassociated with insulin resistance of patients with type 2 diabetes
- VernacularTitle:多种脂源性细胞因子与2型糖尿病患者胰岛素抵抗相关
- Author:
Liping WANG
;
Bin SONG
;
Yan DAI
;
Hui CHEN
;
Zhenwen ZHANG
;
Caifeng YAN
;
Yunlong PAN
- Keywords:
leptin;
TNF-α;
APN;
CTRP3;
T2DM;
insulin resistance
- From:
Basic & Clinical Medicine
2017;37(9):1247-1250
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relation of fat cells factor and insulin resistance in type 2 diabetes.Methods 60 patients were divided into obesity group, non-obese group and normal control group.To detect the FINs, FPG, TG, TC, LDL,HDL,APN,CTRP3,leptin and TNF-α, according to the formula of HOMA,to analyze the correlation between indicators.Results 1).Compared with normal control group, DM group significantly decrease serum APN, CTRP3 level, compared with non-obesity group, obesity group APN, CTRP3 level significantly decreased(P<0.05 or P<0.01).The leptin level elevated (P<0.05).2)APN concentration and age, BMI, FPG, TG, TC, LDL, FINs, HOMA-IR has negative correlation;CTRP3 andFPG,FINs, HOMA-negative correlation IR(P<0.05), TG was positively correlated (P<0.05);TNF-α and FPG and positively correlated (P< 0.05).Conclusions T2DM patients` serum APN, CTRP3 and high Leptin levels are closely associated with obesity, HOMA-IR, FPG and TG as an independent factor can be used as a new sensitive index of evaluating the degree of insulin resistance.
