The effects of frontal rhytidectomy by BTX-A injection on sebum secretion and quality
10.3760/cma.j.issn.1008-1372.2017.04.013
- VernacularTitle:A型肉毒毒素对除皱后额部皮肤油脂分泌及皮肤质地的影响
- Author:
Hao ZHANG
- Keywords:
Botulinum toxins/TU;
Rhytidoplasty;
Sebaceous glands/SE;
Skin
- From:
Journal of Chinese Physician
2017;19(4):530-532
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of frontal rhytidectomy by different injection site of botulinum toxin type A on sebum secretion and quality.Methods Thirty-two volunteers with forehead ryhtides (moderate to severe) were received frontal rhytidectomy by BTX-A (BOTOX) intramuscular injection which was administered to 5 injective sites,and randomly divided into 2 groups according to different injection site (Dermal injection group and muscle injection group).Baseline and post-treatment (2,4,6,8 weeks after injection) sebum production (the region 0.5 cm far around injection point,the region 0.6 1.5 cm far around injection point) and elasticity were measured.Results Significant reduction of sebum secretion was showed on the regions of 0.5 cm far around injection point and 0.6-1.5 cm far around injection point after BTX-A injection for 4,8 weeks (P ＜ 0.05).4 weeks after treatment,the levels of sebum secretion in two regions were (94.6 ± 10.3)μg/cm2 and (97.2 ± 11.2) μg/cm2,which significantly decreased in dermal injection group than those of muscle injection group [(106.2 ± 12.7)μg/cm2,(107.2 ±9.4)μg/cm2,t =7.62,6.73,P ＜0.05].The levels of R2,R5 and R7 increased significantly in two groups after 4 weeks treatment (P ＜ 0.05),and the levels decreased from 8 weeks after treatment and no significant difference was observed after 16 weeks (P ＞ 0.05).Conclusions Intramuscular injection of BTX-A could reduce the sebum secretion of the region 1.5 cm far around the injection point after 4 weeks and 8 weeks treatment,and increase the elasticity after 4 weeks treatment.
