Effect of general anesthesia combined with epidural anesthesia on gut barrier function in patients undergoing endoscopic radical gastrectomy
10.3760/cma.j.issn.1008-6706.2017.19.011
- VernacularTitle:全身麻醉复合硬膜外腔阻滞麻醉对腔镜下胃癌根治切除术后肠屏障功能的影响
- Author:
Wenjie ZHANG
;
Yuntong GUO
;
Yan LI
;
Xin WANG
;
Zhiping CAO
;
He HUANG
- Keywords:
Epidural anesthesia;
General anesthesia;
Intestinal barrier function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(19):2921-2925
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of general anesthesia combined with epidural block anesthesia on intestinal barrier function in patients with gastric cancer after radical resection.Methods 90 patients with gastric cancer undergoing laparoscopic radical resection were selected.They were randomly divided into observation group (epidural anesthesia plus general anesthesia) and control group (general anesthesia),45 cases in each group.The intraoperative blood loss,intraoperative infusion volume,postoperative exhaust time,postoperative complications and the function of intestinal barrier effects were compared between the two groups.Results The total incidence rate of postoperative complications in the observation group(8.89％) was significantly lower than that in the control group (28.89％) (x2 =4.83,P ＜ 0.05).The hospital stay in the observation group [(12.5 ± 4.23) d] was significantly shorter than that in the control group [(17.5 ± 5.26) d] (t =3.27,P ＜ 0.05).The two amine oxidase [(3.88 ± 0.98) U/L],D-lactic acid [(7.44 ± 5.23) mg/L],endotoxin [(13.44 ± 2.12) U/L] levels of the observation group were significantly lower than those of the control group [two amine oxidase (11.33 ± 1.25) U/L,D-lactic acid (15.34 ±3.21) mg/L,endotoxin (21.03 ± 0.82) U/L] (t =5.63,5.02,4.19,all P ＜ 0.05).Conclusion Compared with total intravenous anesthesia,total intravenous anesthesia combined with epidural anesthesia is beneficial to the recovery of intestinal barrier function after radical gastrectomy,and can shorten the postoperative hospital stay.It is worthy of clinical application and popularization.
