Analysis on influence factors of autologous peripheral blood stem cell mobilizationand collection in 48 patients with non-Hodgkin′s lymphoma
10.3969/j.issn.1671-8348.2017.24.005
- VernacularTitle:48例非霍奇金淋巴瘤患者自体外周造血干细胞动员采集的影响因素分析
- Author:
Yiying XIONG
;
Lin LIU
;
Xiaoqiong TANG
;
Qing XIAO
;
Hongbin ZHANG
;
Jianyu WANG
;
Li WANG
- Keywords:
lymphoma;
non-hodgkin;
hematopoietic stem cells;
peripheral blood stem cell transplantation;
factor analysis;
statistical
- From:
Chongqing Medicine
2017;46(24):3328-3331
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively analyze the influence factors during autologous peripheral blood stem cell (PBSC) mobilization and collection process in the patients with non-Hodgkin′s lymphoma (NHL).Methods Forty-eight patients with NHL in our hospital from January 2014 to August 2016 underwent PBPC mobilization and collection.The factors of age,sex,disease stage,bone marrow involvement at diagnosis,chemotherapy frequency,relapse and so on were analyzed retrospectively.Results PBSC mobilization and collection was successful in 37 cases (77.10%).The success rate was affected by the time from diagnosis to mobilization (P=0.038),chemotherapy courses (P=0.016),prior chemotherapy including fludarabine (P=0.049),relapse(P=0.033),and the levels of white blood cell (P=0.014) and platelet (P<0.01) before stem cells collection.Conclusion For the patients planning to receive autologous peripheral blood stem cell transplantation,many times of prior chemotherapy are unfavorable,mobilization and collection should be taken as early as possible,chemotherapeutic agents which possibly injure stem cells should be avoided,it is needed to simultaneously pay attention to peripheral blood WBC and platelet level for determining the collection timing.
