Effects of different administration modes of hydrocortisone sodium succinate on patients with severe sepsis secondary shock
10.3969/j.issn.1671-8348.2017.24.013
- VernacularTitle:氢化可的松琥珀酸钠不同给药方式对重症脓毒性休克患者的影响
- Author:
Ke CHEN
;
Yun LI
;
Hong SU
- Keywords:
hydrocortisone;
shock;
septic;
glucocorticoids;
hydrocortisone sodium succinct;
intravenous infusion;
intravenous micro pump
- From:
Chongqing Medicine
2017;46(24):3354-3355,3369
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of hydrocortisone sodium succinct by intravenous infusion or continuous intravenous micro pumping on the vital signs,shock duration,blood glucose and mortality in the patients with severe sepsis secondary shock.Methods Ninety patients with septic shock treated in our hospital from June 2014 to September 2016 were selected and divided into the control group and observasion group by using the random number table method,45 cases in each group.The control group was given hydrocortisone sodium succinct 200mg/d by slow intravenous drip for 2h,while the observasion group was given hydrocortisone sodium succinct 8.33mg/h by continuous intravenous micro pumping.The two groups were treated for continuous 5 d.The blood glucose,hemodynamics and prognosis were compared between the two groups.Results In the observasion group,the blood glucose indicators such as the time window of high blood glucose,LAGE,MBG and CV levels were lower than those in the control group,the difference had statistical significance (P<0.05).The hemodynamic indicators such as HR,CVP and MAP between the two groups before treatment and at 6,24 h and 5 d after treatment had no statistical difference between the two groups (P>0.05).The shock duration,ICU stay length,total hospital stay and 28 d mortality in the observasion group were lower than those in the control group,but the difference between the two groups had no statistical significance (P>0.05).Conclusion Continuous intravenous micro pumping of hydrocortisone sodium succinct can stabilize blood glucose fluctuation range in the patients with septic shock,but the hemodynamic indexes and prognosis have no obvious improvement.
