Meta-analysis on effect evaluation of estrogen combined with antidepressants in treatingperimenopause-related depression in our country
10.3969/j.issn.1671-8348.2017.24.017
- VernacularTitle:雌激素联合抗抑郁药物治疗我国围绝经期妇女抑郁效果评价的Meta分析
- Author:
Daiyue LIU
;
Mingjie ZHONG
;
Minqing REN
;
Xianfeng LIANG
;
Guhua ZHONG
- Keywords:
estrogens;
perimenopause;
depressive disorder;
combined therapy;
Meta-analysis
- From:
Chongqing Medicine
2017;46(24):3370-3374
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically assess the clinical efficacy of estrogen combined with antidepressants in the treatment of perimenopause-related depression in our country by meta analysis.Methods The electronic databases of CBMdisc,CNKI,VIP,Wanfang,PubMed,Cochrane Library and Google Scholar were retrieved by computer.The subject terms were set for retrieving the literatures on the effect evaluation of estrogen combined with antidepressants in treating perimenopause-related depression in our country published at home and abroad from January 1980 to February 2016.The study data and results of included literatures were performed the meta analysis by using the RevMan 5.1 software.Results Fifteen articles conforming to the inclusion standard were included.The data merged results showed that compared with single estrogen use group,in the aspects of the effective rate(RR=1.46,95%CI=1.29-1.66,P<0.004),HAMD score(WMD=-4.61,95%CI=-5.63——3.59,P<0.01)and KMI score(WMD=-5.83,95%CI=-11.12——0.53,P<0.01),the estrogen combined with antidepressants group had statistically significant difference.Conclusion The treatment and alleviating effect of estrogen substitution therapy combined with antidepressants for treating perimenopause symptoms and depression is superior to that of single estrogen use substitution therapy.
