Preparation of Breviscapine Microemulsion for Parenteral Injection
10.3870/j.issn.1004-0781.2017.09.019
- VernacularTitle:灯盏花素微乳注射剂的制备
- Author:
Qing ZHAO
;
Haigang LI
;
Hao LIU
;
Gui LIN
;
Qingqiang MIN
;
Xiaotong YANG
- Keywords:
Breviscapine;
Microemulsion;
Pseudo-ternary phase diagram
- From:
Herald of Medicine
2017;36(9):1024-1028
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the prescription and preparation technology of breviscapine microemulsion for parenteral injection,and to evaluate its quality.Methods The prescription was selected and optimized through single-factor test and the pseudo-ternary phase diagram method.The preparation technology was investigated,and the particle diameter,drug content,encapsulation efficiency and haemolyticus were evaluated.Results The prescription composition of breviscapine microemulsion was soybean oil:phospholipid:HS15:PEG400:water=1:0.1:0.55:0.55:6.64 (m/m),with the drug content of 4.01 mg·mL-1,the acquired breviscapine microemulsion exhibited light yellow,uniform and transparent,with average particle diameter of 92.1 nm and encapsulation efficiency of 96.8%.The compatibility test showed no drug precipitation and the preparation was no hemolytic crisis.Conclusion The preparation of breviscapine microemulsion injection is correspond to the main index of parenteral injection.
