Establishment of rabbit model of acute pulmonary embolism with right ventricular dysfunction
10.13929/j.1672-8475.201611008
- VernacularTitle:急性肺栓塞致右心功能不全兔模型的建立
- Author:
Zhenyu JIA
;
Guangdong LU
;
Jinxing ZHANG
;
Linbo ZHAO
;
Sheng LIU
;
Haibin SHI
- Keywords:
Pulmonary embolism;
Ventricle dysfunction,right;
Model,animal
- From:
Chinese Journal of Interventional Imaging and Therapy
2017;14(3):178-181
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish an easily reproducible rabbit model of acute pulmonary embolism (APE) with right ventricular dysfunction (RVD).Methods Two gelfoam strips (5 rnm×5 mm× 10 mm) were squeezed and were introduced into the pulmonary arteries of each healthy rabbit (n=12).Pulmonary and systemic hemodynamic function were recorded.All rabbits underwent CT pulmonary angiography (CTPA) and pathological examination after the introduction of APE.Results All gelfoam strips located in the bilateral lower lobe arteries.Compared with baseline mean pulmonary artery pressure (mPAP) ([9.75±1.75] mmHg),mPAP increased to (20.58 ± 5.86) mmHg immediately after embolism (P ＜ 0.001),and then decreased to (18.78 ±4.80) mmHg 1 h after embolism (P＜0.001).Right ventricle/left ventricle diameter ratio (RV/LV) increased from baseline (0.67±0.09) to (1.90±0.28) 45 min after embolism (P＜0.001).Conclusion An easily reproducible rabbit model of APE with RVD are established and may be suitable for study of APE pathophysiology.
