Safety and efficacy of tirofiban in stent-assisted coil embolization in intracranial aneurysms
10.13929/j.1672-8475.201611013
- VernacularTitle:替罗非班在支架辅助颅内动脉瘤栓塞中的安全性及有效性
- Author:
Rutao MOU
;
Yizhi LIU
;
Caifang NI
;
Long CHEN
;
Bo LI
- Keywords:
Aneurysm;
Embolism;
Tirofiban;
Stents;
Safety
- From:
Chinese Journal of Interventional Imaging and Therapy
2017;14(3):129-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the safety and efficacy of tirofiban in stent-assisted coil embolization of intracranial aneurysms.Methods Totally 31 patients who were treated using stent-assisted coil embolization were analyzed retrospectively.All the patients were divided into aspirin combined clopidogrel group (double resistance group,n=18) and tirofiban group (n=13).Tirofiban was injected after the stent was semi-released or released completely.The patients were followed-up after operation to assess whether the patient had a new infarction,stent patency and aneurysm embolization effect.One day before operation and 3 days after operation,platelet count and activated thromboplastin time (APTT) were detected respectively.Score Glasgow (GOS) was used to evaluate the clinical outcome of patients and the operative complications were recorded.Results A total of 34 aneurysms were found in 31 patients,and 32 aneurysms were treated.Urinary tract hemorrhage was founded in 1 case and recurrent aneurysms were founded in 7 cases after embolization.None of the patients developed thrombocytopenia,retroperitoneal and gastrointestinal bleeding related to tirofiban administration.There were no postoperative cerebral infarction and thrombosis events.GOS of 27 cases were ≥4.Platelet count and APTT 1 day before and 3 days after operation had no statistically significance between two groups (both P＞0.05).Conclusion It is safe and effective for tirofiban in stent-assisted aneurysm embolization and can be used as an alternative to the dual resistance.
