The Mechanism Study of the Rapid Antidepressant Effects of Yueju Pill on Depression of Parkinson's Disease
10.11842/wst.2017.02.016
- VernacularTitle:越鞠丸快速改善帕金森病抑郁的机制研究
- Author:
Xing WANG
;
Juanjuan TANG
;
Chang CHEN
;
Weiwei TAO
;
Wenda XUE
;
Li REN
;
Hongquan LIU
;
Xiaoyan GUO
;
Gang CHEN
- Keywords:
Yueju pill;
rapid antidepression;
depression of Parkinson's disease
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(2):289-294
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed at exploring the mechanism of the rapid antidepressant effects of Yueju pill on depression of Parkinson's disease (DPD).The fast antidepressant effects of Yueju pill in this study was evaluated by behavior tests,such as open field test (OFT),tail suspension test (TST),forced swimming test (FST) and sucrose preference test (SPT) according to the modeling method of subacute DPD in the literature.In vitro experiment was implemented using PC12 cells.Moreover,the protective effects of Yueju pill on 1-methyl-4-phenylpyridinium (MPP+) induced neural injury with the engagement of cAMP response element binding protein (CREB) were expounded.As a result,it was found that the immobility time of the mice in the model group was significantly longer than that in the normal group in TST and FST tests (P ＜ 0.01),and the SPT ratio of mice in the model group remarkably decreased (P ＜ 0.01).In addition,the immobility time of DPD mice was shortened in the FST test after administering Yueju pill (P ＜ 0.05),while the SPT ratio was increased (P ＜ 0.01).Yueju pill took the effects on the third day after a single administration.The phosphorylation of CREB (p-CREB) in MPP+ induced PC12 cells was decreased in comparison with the model group,while the expression of p-CREB was up-regulated with the administration of Yueju pill (P ＜ 0.01).In conclusion,DPD was quickly mitigated after the treatment of Yueju pill,the activation of CREB signaling pathway and its neuroprotective effects may be the mechanism behind it.
