Preparation and in Vitro Properties of Paeonol Thermo Sensitive Gel
10.11842/wst.2017.02.030
- VernacularTitle:丹皮酚温度敏感型凝胶的制备及体外性能探索
- Author:
Na QI
;
Xinping YANG
;
Anli TANG
;
Ying LIAO
;
Shengjiu GU
- Keywords:
Paeonol;
thermosensitive gel;
poloxamer 407;
poloxamer 188;
in vitro release
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(2):375-380
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed at preparing paeonol thermosensitive gel and preliminary exploring its properties in vitro.Tube inversion method was adopted to investigate the effects of concentrations of poloxamer 407 and poloxamer 188 on gelation temperature.Then,viscosity of the gel was detected by rotary viscometer,and in vitro erosion and drug release characteristics of the gel by no film stripping method.As a result,the gelation temperature of poloxamer 407 decreased with the increase of its concentration,while gelation temperature of poloxamer 407 increased with the accelerating concentration of poloxamer 188.The cumulative drug release of paeonol thermo sensitive gel was up to 70％ in 320 rin.Gel dissolution and drug release were simultaneously performed without burst release phenomenon.It was concluded that the preparation process of paeonol thermo sensitive gel was simple and easy to use with the overt effect of sustained-release.
